2TheApex: Yes! Last June the FDA approved an anesthetic nasal spray (Kovanaze) for use in restorative procedures on teeth #4 through #13. It takes two squirts 5 minutes apart (a third squirt may be needed sometimes). One big advantage, in addition to calming patients with a needle phobia, could be pulpal anesthesia without lip numbness for esthetic cases. Use for root canal treatment or biopsy has not been studied yet. Kovanaze is reported to be available sometime this fall.  Recent Study  Manufacturer Press ReleaseExplanation with diagrams from Spear Education